Thrilling Moment of an Inhibitory Channel
نویسندگان
چکیده
Long thought to be potassium channels with calming influence quietly working away in the background, in this issue of Neuron, Thomas et al. demonstrate that K(2P)2.1 (TREK-1) channels have two endogenous isoforms due to a mechanism called alternative translation initiation (ATI). Hence, they can actually be excitable.
منابع مشابه
Inhibitory effect of Ketotifen on rat isolated uterus contraction in compare with a β2-adrenoceptor agonist and an ATP-dependent K channel activator
کتوتیفن یک بنزوسیکلوهپتاتیوفن با فعالیت های متعدد فارماکولوژیکی از جمله اثر مهاری بر روی انقباضات روده و مثانه است ولی اثرات این دارو بر روی رحم بررسی نشده است. در این تحقیق اثر کتوتیفن بر روی انقباضات ناشی از استیل کولین و کلرید پتاسیم در رحم جدا شده رات (In vitro) توسط دستگاه فیزیوگراف اندازه گیری و با اثر متاپروترنول و دیازاکسید مقایسه گردید. کتوتیفن انقباضات ناشی از کلرید پتاسیم را به صورت ...
متن کاملAn approximate model for slug flow heat transfer in channels of arbitrary cross section
In this paper, a novel approximate solution to determine the Nusselt number for thermally developed, slug (low-prandtl), laminar, single phase flow in channels of arbitrary cross section is presented. Using the Saint-Venant principle in torsion of beams, it is shown that the thermally developed Nusselt number for low-prandtl flow is only a function of the geometrical parameters of the channel c...
متن کاملThe Antiiflammtory Activity of calcium-channel antagonists on chronic inflammation in rat
calcium mobilization is known to be an important factor in the activation of cells involved in inflammation,so,calcium-channel antagonists are be expected ti exhibit antiinflammatory activity.in the present study,we evaluateted the antiinflammatory effects of two calcium channel blockers,verapamil and nifedipine on adjuvant induced chronic in flammation in rat paw.sixty adult male rats were div...
متن کاملPerformance Improvement of PEM Fuel Cells Using Air Channel Indentation; Part I: Mechanisms to Enrich Oxygen Concentration in Catalyst Layer
A three dimensional, compressible, steady, one phase flow of reactant-product mixture in the air side electrode of proton exchange membrane fuel cell (PEMFC) is numerically studied in this paper. The mixture is composed of three species: oxygen, nitrogen and water vapor. The performance of the cell is enhanced by partial blockage of the flow field channels. Various types of these blocks also ca...
متن کاملThe Effectiveness of De-Disease Therapy through Eye Movements and Reprocessing on Cognitive Thrilling Adjustment in Addicted Patients in Yasuj
Introduction: In Iran, over the past 20 years, the prevalence of drug abuse has more than doubled the population growth rate. In order to cope with this problem, psychotherapy approaches have gradually expanded in recent years and an important issue in abandoning addiction is the reason for abandoning addiction. The purpose of this study was to evaluate the effectiveness of sensitization thro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Neuron
دوره 58 شماره
صفحات -
تاریخ انتشار 2008